Leo R Fitzpatrick Selected Research

Orphan Nuclear Receptors

4/2020

VPR-254: an inhibitor of ROR-gamma T with potential utility for the treatment of inflammatory bowel disease.

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Leo R Fitzpatrick Research Topics

Disease

14	Colitis 04/2020 - 05/2002
11	Inflammation (Inflammations) 01/2022 - 05/2007
6	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 04/2020 - 03/2007
2	Autoimmune Diseases (Autoimmune Disease) 12/2014 - 10/2010
2	Disease Progression 04/2010 - 04/2008
2	Crohn Disease (Crohn's Disease) 04/2010 - 03/2007
2	Ulcerative Colitis 04/2008 - 03/2007
1	Ischemia 01/2022
1	Acute Kidney Injury (Acute Renal Failure) 01/2022
1	Sepsis (Septicemia) 01/2022
1	Arthritis (Polyarthritis) 04/2011
1	Experimental Arthritis 04/2011
1	Pain (Aches) 01/2011
1	Osteoarthritis 01/2011
1	Fibrosis (Cirrhosis) 03/2010

Drug/Important Bio-Agent (IBA)

6	Dextran SulfateIBA 04/2020 - 07/2006
5	Interleukin-17 (Interleukin 17)IBA 04/2020 - 10/2010
4	sphingosine kinaseIBA 01/2022 - 04/2008
4	CytokinesIBA 04/2020 - 05/2002
4	Sulfonic AcidsIBA 12/2014 - 03/2010
3	3- (4- chlorophenyl)- adamantane- 1- carboxylic acid (pyridin-4-ylmethyl)amideIBA 04/2011 - 04/2010
3	NF-kappa B (NF-kB)IBA 09/2008 - 05/2002
2	SphingolipidsIBA 01/2022 - 01/2011
2	AcidsIBA 04/2020 - 01/2020
2	Dextrans (Dextran)FDA Link 01/2020 - 10/2010
2	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2020 - 10/2010
2	vidofludimusIBA 09/2012 - 10/2010
2	HaptensIBA 09/2012 - 03/2010
2	olsalazine (Dipentum)FDA Link 04/2010 - 04/2008
2	EnzymesIBA 04/2010 - 04/2008
2	Peptides (Polypeptides)IBA 03/2007 - 07/2006
2	Polysaccharides (Glycans)IBA 04/2003 - 05/2002
2	Peptidoglycan (Murein)IBA 04/2003 - 05/2002
1	LipopolysaccharidesIBA 01/2022
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 04/2020
1	Transcription Factors (Transcription Factor)IBA 04/2020
1	Orphan Nuclear ReceptorsIBA 04/2020
1	Member 3 Group F Nuclear Receptor Subfamily 1IBA 04/2020
1	bile acid binding proteinsIBA 01/2020
1	sodium-bile acid cotransporterIBA 01/2020
1	Bile Acids and Salts (Bile Acids)IBA 01/2020
1	Opioid Receptors (Opioid Receptor)IBA 01/2020
1	Opioid Analgesics (Opioids)IBA 01/2020
1	7-benzylidenenaltrexoneIBA 01/2020
1	naltrindoleIBA 01/2020
1	Naltrexone (ReVia)FDA LinkGeneric 01/2020
1	FlavonoidsIBA 07/2017
1	1- (2- cyano- 3,12- dioxooleana- 1,9- dien- 28- oyl) imidazoleIBA 12/2014
1	TriterpenesIBA 12/2014
1	Interleukin-10 (Interleukin 10)IBA 05/2014
1	melanin-concentrating hormone (melanin concentrating hormone)IBA 05/2014
1	Vancomycin FDA LinkGeneric 10/2012
1	Indomethacin (Indometacin)FDA LinkGeneric 04/2011
1	SphingosineIBA 01/2011
1	Dihydroorotate DehydrogenaseIBA 10/2010
1	Dexamethasone (Maxidex)FDA LinkGeneric 10/2010
1	sym-trinitrobenzeneIBA 03/2010
1	Metronidazole (Metric)FDA LinkGeneric 09/2008
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 04/2008
1	NF-KappaB Inhibitor alphaIBA 05/2007
1	Peroxidase (Myeloperoxidase)IBA 05/2007
1	InterleukinsIBA 05/2007
1	Proteasome Endopeptidase Complex (Proteasome)IBA 03/2007
1	GliotoxinIBA 05/2002

Therapy/Procedure

1	Nephrectomy 01/2022
1	Therapeutics 01/2020
1	Oral Administration 10/2010
1	Immunomodulation 09/2008